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Step-by-Step Guidance on Cleanroom Construction

There are many discrete steps in designing and planning a cleanroom construction. It includes incorporating specific projects promoting the construction process flow towards within budget and on-time completion. Proper front end planning gets completed only when it includes design parameter values and transparent design for the designing phase. Engineering the cleanroom design according to the recording industrial practices will create transparent construction planning and procurement. 


You must realize a complete energy return through the construction phase with a well-executed certification process and a start-up. It will offer the best baseline data for efficient maintenance and operation. This blog will describe the detailed steps in cleanroom construction and provide practical recommendations on avoiding pitfalls on the way. 


What is a Cleanroom Construction?


A cleanroom is an enclosed area within the drug research and manufacturing facility. It is particularly designed for managing the levels of air pollutants. Cleanroom construction should meet all the crucial environmental conditions like pressurization, humidity, personal access, and temperature. 


Apart from the pharmaceutical industry, cleanrooms are also essential for the biotechnology, microelectronics, food packaging, and life science sectors. It protects the procedures or any products from any contamination. Different types of contaminants against which cleanroom construction projects include:


  • Microbes

  • Toxic vapors

  • Dust

  • Skin flakes

  • Clothing fibers

  • Hair

  • Paint and coatings

  • Paper

  • pencils


FAQ


What are the different types of cleanrooms present?


Cleanrooms are classified according to the level of clean air present in them. There must be enough air filtration in the cleanroom to get rid of and keep away all the airborne contaminants. There are usually two types of cleanrooms: unidirectional and turbulently vented flow.


How does an experienced pharma consulting company help in cleanroom construction?


An experienced pharma consultant company will have expertise in cleanroom design. They know the facility's size and complexity. They can design, build, procure, construct, or combine different services. The designing team is the best resource during the planning phase of front-end planning. They demonstrate their knowledge in space planning, electrical and mechanical design, contamination controlling philosophies, code compliance and more. The company will also prevent any unrealistic construction schedule and field rework. 


Step by Step Process of cleanroom construction


Cleanroom construction includes the following processes.


  • Preliminary design


The designing team starts with the cleaning facility plan by including the process requirements, safety issues, utility requirements, code requirements, and personnel and material flow. Preliminary design is a target that assists in solidifying the goals. 


  • Front end planning


The cleanroom air is purified with HEPA (High-Efficiency Particulate Air) filters to achieve the necessary surrounding conditions. In this process, air enters the filters with force and removes small particles. 


  • Evaluating the layout for material flow


It is vital to examine the material flow in the cleanroom. The crucial spaces should include single access and prevent the space from one pathway to the other. You should evaluate the cross-contamination of the process for inflow routes of the raw material, finished product, isolation of material process, and containment.


  • Determining the air balance of the space


In this space, the team decides the cleanroom supply, exfiltration, return airflows, exhaust, and more. The final airflow will get adjusted in the start-up phase for unplanned air exfiltration. 


  • Construction


Cleanroom construction protocol is maintained during this phase, and an integral bidding document is formed. 


End Thoughts


So these are the step-by-step process of a cleanroom design and construction. It assists in focusing attention and resulting in a successful project. A well-conceived and scheduled construction project will require thorough assessments, preliminary designs, and front-end planning. You should always measure the project's progress against the overall schedule. 
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Location: India

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